By Robert N. Klein II

California’s Proposition 71 has made possible the development of a new model for government funding of stem cell research and therapy development. The $3 Billion California Model proposes that with world-class scientific talent and facilities, the funding source redefines the scope, complexity, and time frames for medical discoveries, and the application of the medical technologies discovered and developed. The funding must be protected from pressures and distortions to the scientific discovery process. Long-term funding commitments are critical to provide adequate assurance to attract the best scientific talent. Stable funding is critical to assure those taking on long-term scientific challenges of the capacity to carry the best discoveries through the development process to patients. The capital source must provide sufficient financial scale so critical mass can be achieved in the field, with a broad portfolio of potential therapies and treatments. Resource allocation must be based on objective scientific criteria, allowing research to be funded across an integrated pipeline from basic research through Phase II human clinical trials for proof of efficacy.